Out of all Rush Limbaugh's cameos, none are more famous than his appearances on Family Guy. He was the star of the episode "Excellence in Broadcasting,” where he converted the usually liberal family dog Brian to conservatism — after saving him from a mugging, that is. The episode dove into Brian's psyche and what makes him tick, and it also featured the famous "Republican Town" song. While Limbaugh eventually used his signature brand of criticism to snap Brian back to liberalism, the episode wasn't Limbaugh's only visit to Quahog.

Limbaugh also had two smaller Family Guy cameos, and in their Star Wars parodies, no less. In the episode "Blue Harvest," Limbaugh cameoed as a Tatooine talk radio host who lampooned his real-life stances on global warming and affirmative action by claiming Hoth isn't melting and discussing how Lando Calrissian became leader of Cloud City. Moreover, according to the episode's IMDB page, Limbaugh voiced Red 6. Limbaugh appeared one final time in the episode "It's a Trap!" as a giant, Rancor-like beast that spent less time trying to eat Chris Griffin (who filled in for Luke Skywalker) and more time criticizing the Jedi Order's tax-exempt status. Like the Rancor in Return of the Jedi, Rush Limbaugh's final scene in Family Guy consisted of his skull being crushed by a closing gate.